Department of Food and Nutrition, Sahmyook University, Seoul, 01795, South Korea.
Department of Food Science, KC University, Seoul, 07661, South Korea.
Adv Exp Med Biol. 2017;975 Pt 2:975-987. doi: 10.1007/978-94-024-1079-2_77.
The purpose of this study was to examine the effects of taurine on lipid levels and liver function and the actions of insulin and leptin by biochemically analyzing the blood of albino mice fed a diet containing 20% taurine. The group fed a high-fat diet (HF) containing 20% taurine (HF + taurine 20%) showed higher blood HDL cholesterol levels as well as significantly lower total cholesterol and triglyceride levels (p < 0.05) than the group fed HF. No significant difference was observed among indicators of liver function, such as alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase activities. However, the HF + taurine 20% group showed significantly lower insulin and leptin levels than the HF group (p < 0.05). These findings show that 20% taurine had a significant effect on blood lipid levels and blood sugar maintenance in mice fed an HF.
本研究旨在通过生化分析喂养含 20%牛磺酸饮食的白化小鼠的血液，来研究牛磺酸对血脂水平和肝功能以及胰岛素和瘦素作用的影响。与喂食高脂肪饮食（HF）（含 20%牛磺酸）的组（HF + 牛磺酸 20%）相比，喂食 HF + 牛磺酸 20%的组的血液高密度脂蛋白胆固醇水平更高，总胆固醇和甘油三酯水平显著降低（p < 0.05）。碱性磷酸酶、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶和乳酸脱氢酶等肝功能指标无显著差异。然而，HF + 牛磺酸 20%组的胰岛素和瘦素水平明显低于 HF 组（p < 0.05）。这些发现表明，20%的牛磺酸对喂食 HF 的小鼠的血脂水平和血糖维持有显著影响。
