Strzyzewski W, Rybakowski J, Kapelski Z
Neuropsychobiology. 1980;6(3):121-7. doi: 10.1159/000117789.
Water and electrolyte contents in plasma and red blood cells (RBC) were studied in 46 patients with depressive syndromes of various etiology (bipolar, unipolar, psychogenic) before and after 14 days of imipramine treatment. Initial low RBC sodium levels were characteristic of patients with bipolar depression. A significant increase in RBC sodium was observed after imipramine treatment in a group of good imipramine responders. RBC sodium changes in psychogenic patients after imipramine were different from those observed in endogenous (bipolar plus unipolar) ones. A fall in plasma calcium levels was shown in the course of imipramine administration mostly in patients with favourable response to the drug.
对46例患有各种病因（双相、单相、心因性）抑郁综合征的患者，在接受丙咪嗪治疗14天前后，研究了血浆和红细胞（RBC）中的水和电解质含量。双相抑郁症患者最初的红细胞钠水平较低。在丙咪嗪治疗后，一组对丙咪嗪反应良好的患者红细胞钠显著增加。心因性患者在丙咪嗪治疗后的红细胞钠变化与内源性（双相加单相）患者不同。在丙咪嗪给药过程中，血浆钙水平下降主要出现在对该药物反应良好的患者中。
