Shikhsaidov I I
Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):3-6.
The effect of obsidan, mercazolil and their combinations on the plasma and erythrocytic potassium and sodium content as well as on the plasma calcium and magnesium concentration was studied under clinical conditions in 107 patients with a visceropathic stage of toxic goitre. Obsidan was given orally in a dose of 1.5 to 2 mg/kg and mercazolil in a dose of 0.5 mg/kg daily within 10 successive days. Obsidan treatment led to an increase in plasma and erythrocytes of the potassium concentration and plasma magnesium content, while the level of sodium in plasma and erythrocytes as well as of plasma calcium reduced. Mercazolil treatment (control group) exerted no significant effect on the test characteristics. It is concluded that obsidan effect on the blood calcium and sodium concentration is mediated through its action on the renin-angiotensin-aldosterone system.
在临床条件下，对107例患有毒性甲状腺肿内脏病变期的患者，研究了奥西丹（Obsidan）、甲巯咪唑（mercazolil）及其组合对血浆和红细胞中钾、钠含量以及血浆钙、镁浓度的影响。连续10天，每天口服给予奥西丹，剂量为1.5至2毫克/千克，甲巯咪唑剂量为0.5毫克/千克。奥西丹治疗导致血浆和红细胞中钾浓度以及血浆镁含量增加，而血浆和红细胞中的钠水平以及血浆钙水平降低。甲巯咪唑治疗（对照组）对检测指标无显著影响。得出的结论是，奥西丹对血钙和血钠浓度的影响是通过其对肾素 - 血管紧张素 - 醛固酮系统的作用介导的。
