Melsen F, Mosekilde L
Calcif Tissue Res. 1978 Dec 8;26(2):99-102. doi: 10.1007/BF02013242.
A histomorphometric evaluation of the iliac crest trabecular bone remodeling was performed after tetracycline double-labeling in 41 normal Danes (12 males and 29 females) aged 19 to 56 years. The fraction of formative (osteoid covered) and resorptive surfaces was unrelated to age but higher in males than in females (P less than 0.02 and P less than 0.05, respectively). The appositional rate (0.65 +/- 0.12 micrometer/day) was unrelated to age and sex, whereas the fractional labeled surfaces were higher (P less than 0.01) in the males (0.18 +/- 0.08 micrometer2/micrometer2) than in the females (0.12 +/- 0.05 micrometer2/micrometer2), and among the females inversely related to age (R = -0.38, P less than 0.05). The bone formation rate at BMU level (0.50 +/- 0.20 micrometer3/micrometer2/day) was unrelated to sex, but among the females inversely related to age R = -0.49, P less than 0.01). The bone formation rate at tissue level was higher (P less than 0.02) in the males (0.13 +/- 0.07 micrometer3/micrometer2/day) than in the females (0.07 +/- 0.03 micrometer3/micrometer2/day) and among the females inversely correlated to age (R = -0.43, P less than 0.05). the age- and sex-dependent variations in the dynamic parameters underline the importance of a more elaborated normal material.
对41名年龄在19至56岁的正常丹麦人（12名男性和29名女性）进行四环素双标记后，对髂嵴小梁骨重塑进行了组织形态计量学评估。形成性（类骨质覆盖）表面和吸收性表面的比例与年龄无关，但男性高于女性（分别为P<0.02和P<0.05）。沉积率（0.65±0.12微米/天）与年龄和性别无关，而标记表面分数在男性（0.18±0.08微米²/微米²）中高于女性（0.12±0.05微米²/微米²）（P<0.01），并且在女性中与年龄呈负相关（R=-0.38，P<0.05）。骨小梁水平的骨形成率（0.50±0.20微米³/微米²/天）与性别无关，但在女性中与年龄呈负相关（R=-0.49，P<0.01）。组织水平的骨形成率在男性（0.13±0.07微米³/微米²/天）中高于女性（0.07±0.03微米³/微米²/天）（P<0.02），并且在女性中与年龄呈负相关（R=-0.43，P<0.05）。动态参数中年龄和性别依赖性变化强调了更详细正常数据的重要性。
