Blumenkrantz N, Asboe-Hansen G
Scand J Rheumatol. 1980;9(1):1-5.
Decreased biosynthesis of (14C) hydroxyproline in skin collagen was observed after injection of the flavonoid (+)catechin into guinea pigs. No alteration in already synthesized collagens was noted, as measured by the content of hydroxyproline and hydroxylysine. No alteration in the content of skin acid glycosaminoglycans was observed. The variable binding of (+)catechin to different tissues was demonstrated. No special sensitivity to the drug of any collagen type was found.
给豚鼠注射类黄酮（+）儿茶素后，观察到皮肤胶原蛋白中（14C）羟脯氨酸的生物合成减少。通过羟脯氨酸和羟赖氨酸的含量测定，未发现已合成的胶原蛋白有任何改变。未观察到皮肤酸性糖胺聚糖含量的变化。证明了（+）儿茶素与不同组织的可变结合。未发现任何胶原类型对该药物有特殊敏感性。
