Blumenkrantz N, Asboe-Hansen G
Scand J Rheumatol. 1978;7(1):55-60.
The effect of (+)catechin on connective tissue was studied in organ cultures of chick embryo tibiae and after in vivo injection in rats and mice. Collagen biosynthesis and hydroxylation of 14C-Pro-labelled protocollagen in vitro by protocollagen proline hydroxylase (PPH) were inhibited. In vivo, a slight decrease in the biosynthesis of collagen and in the PPH activity in skin of rats and mice was noticed as an effect of (+)catechin. No effect of the drug was observed on the incorporation of 14C-D-glucosamine by chick embryo tibiae. Increased urinary excretion of acid mucopolysaccharide metabolites by the mice injected with (+)catechin was observed.
研究了（+）儿茶素对鸡胚胫骨器官培养物以及对大鼠和小鼠进行体内注射后的结缔组织的影响。原胶原脯氨酸羟化酶（PPH）在体外对14C-脯氨酸标记的原胶原的胶原生物合成和羟化作用受到抑制。在体内，作为（+）儿茶素的作用，观察到大鼠和小鼠皮肤中胶原生物合成及PPH活性略有下降。未观察到该药物对鸡胚胫骨摄取14C-D-葡萄糖胺有影响。观察到注射（+）儿茶素的小鼠酸性粘多糖代谢产物的尿排泄增加。
