Martio J, Kiviniemi P, von Essen R, Isomäki H, Akimova T, Ievleva L, Trofimova T, Mylov N
Scand J Rheumatol. 1980;9(1):39-43.
In 1974-76 patients with early rheumatoid arthritis (duration less than or equal to 6 months) were investigated at the Institute for Rheumatism, Moscow, and at the Rheumatism Foundation Hospital, Heinola, Finland. Of 200 patients in each centre, 142 sex- and age-matched patients were chosen and followed up for one year. Despite common selection criteria, appreciable differences were found in clinical involvement, X-ray findings and laboratory results. Many of these may be due to difficulties in the standardization of methods rather than to actual national differences in the clinical picture and course of the disease. In both institutions, almost every patient was given systemic antirheumatic drugs, but there were notable differences in the choice of drugs: gold was preferred at Heinola, chloroquine or cytostatics were more commonly used in Moscow. The use of both local and peroral corticosteroids was similar, while surgery was used only in Heinola and spa treatment only in Moscow.
1974年至1976年期间，莫斯科风湿病研究所和芬兰海诺拉风湿病基金会医院对早期类风湿性关节炎患者（病程小于或等于6个月）进行了调查。每个中心有200名患者，从中选取了142名性别和年龄匹配的患者，并进行了为期一年的随访。尽管选择标准相同，但在临床受累情况、X线检查结果和实验室检查结果方面仍发现了明显差异。其中许多差异可能是由于方法标准化存在困难，而非疾病临床表现和病程的实际国别差异所致。在这两家机构中，几乎每位患者都接受了全身性抗风湿药物治疗，但在药物选择上存在显著差异：海诺拉更倾向于使用金制剂，莫斯科则更常用氯喹或细胞抑制剂。局部和口服皮质类固醇的使用情况相似，而手术仅在海诺拉使用，温泉疗法仅在莫斯科使用。
