Mattern H, Leiendecker U, Krahe T, Harder T
Medizinische Klinik Nord, Universität Bonn.
Dtsch Med Wochenschr. 1988 Mar 25;113(12):453-8. doi: 10.1055/s-2008-1067661.
A retrospective analysis was undertaken of 31 patients with classical or proven chronic rheumatoid arthritis (CRA) who had been on a regimen of basic medication (gold salts, D-penicillamine, chloroquine, azathioprine--alone or in combination). Disease activity was checked by clinical, biochemical, immunological and radiological criteria. The laboratory results could not be altered by the basal medication and there was no relationship with the clinical and radiological findings, except for immunological results. None the less, the clinical symptoms improved under basal medication, even though the functional index got worse. The degree of joint destruction at the beginning and end of the observation period was markedly higher for seropositive than sero-negative cases, without significant differences in the rate of progression of joint destruction. Thus, definite long-term remission was achieved regarding the inflammatory changes but not the progressing joint destruction.
对31例患有典型或确诊为慢性类风湿性关节炎（CRA）的患者进行了回顾性分析，这些患者一直在接受基础药物治疗（金盐、D-青霉胺、氯喹、硫唑嘌呤——单独使用或联合使用）。通过临床、生化、免疫和放射学标准检查疾病活动度。基础药物治疗无法改变实验室结果，且除免疫结果外，与临床和放射学检查结果无关。尽管如此，基础药物治疗下临床症状有所改善，即使功能指数变差。血清阳性患者在观察期开始和结束时的关节破坏程度明显高于血清阴性患者，关节破坏进展率无显著差异。因此，炎症变化实现了明确的长期缓解，但关节破坏仍在进展。
