Gupte S C, Bhatia H M
Vox Sang. 1980;38(1):22-8. doi: 10.1111/j.1423-0410.1980.tb02326.x.
To determine whether tetanus toxoid given during pregnancy increases the risk of haemolytic disease of the new-born, 818 group O pregnant women were given one to three doses of tetanus toxoid during the third trimester. There was a significant increase in the incidence of neonatal jaundice among the ABO-incompatible infants of women given toxoid, compared to a control group. Comparative studies were also done at two hospitals: tetanus toxoid was not given during pregnancy at one hospital and was used routinely at the other. More of the mothers given toxoid had high titres of IgG anti-A or anti-B and more of their ABO-incompatible infants became jaundiced. Thus these studies suggest an increased risk of haemolytic disease of the new-born due to ABO imcompatibility when tetanus toxoid injections are given during pregnancy.
为了确定孕期接种破伤风类毒素是否会增加新生儿溶血病的风险，818名O型血孕妇在孕晚期接种了一至三剂破伤风类毒素。与对照组相比，接种类毒素的女性所生ABO血型不兼容婴儿的新生儿黄疸发病率显著增加。在两家医院也进行了对比研究：一家医院孕期不接种破伤风类毒素，另一家医院则常规使用。接种类毒素的母亲中，更多人有高滴度的IgG抗A或抗B，她们更多的ABO血型不兼容婴儿出现了黄疸。因此，这些研究表明，孕期注射破伤风类毒素会增加因ABO血型不兼容导致新生儿溶血病的风险。
