Deng Zhi-Hui, Seltsam Axel, Ye You-Wan, Yu Qiong, Li Qian, Su Yu-Qing, Liang Yan-Lian, Zang Hao
ShenZhen Institute of Transfusion Medicine, ShenZhen Blood Center, ShenZhen, GuangDong, PR China.
Transfus Apher Sci. 2008 Oct;39(2):123-8. doi: 10.1016/j.transci.2008.07.007.
ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.
胎儿及新生儿ABO溶血病（ABO-HDFN）几乎仅发生于母亲为O型血、所生婴儿为A型或B型血的情况，因为O型血个体比A型或B型血个体更易产生IgG抗A或抗B抗体。我们报告一例具有临床意义的ABO-HDFN病例，母亲为O型血，IgG抗A和抗B效价升高，所产婴儿为A2B血型。母婴之间这种不寻常的ABO血型组合是基于一种罕见ABO等位基因的遗传，该等位基因编码一种能够合成A和B两种抗原的糖基转移酶。由于在该病例中抗A和抗B抗体可能均参与了溶血过程，因此在监测ABO血型不相容的妊娠和分娩时，考虑顺式AB现象可能具有重要意义。
