Cedro A, Herbaczyńska-Cedro K
Cardiovasc Res. 1978 Sep;12(9):516-22. doi: 10.1093/cvr/12.9.516.
Total heart-lung bypass (TBP) for open-heart surgery is often accompanied by a progressive reduction of systemic blood pressure. Since the lung is the main site of elimination of prostaglandins (PGs) from venous blood, TBP may lead to an increase in blood content of vasodilator PGs. TBP was performed in dogs and blood level of prostaglandinlike substances (PLS) was monitored continuously by a bio-assay method. The concentration of PLS increased during TBP to 0.8 ng.cm(-3) blood (in PGE2 equivalents). Restoration of normal circulation led to the disappearance of PLS from the blood. The increase in PLS during TBP was abolished by indomethacin. This was invariably accompanied by elevation of systemic blood pressure. It is suggested that an increased concentration of vasodilator PLS during TBP may contribute to the hypotension observed in total body perfusion.
心脏直视手术中的全心肺转流（TBP）常伴有体循环血压的进行性降低。由于肺是静脉血中前列腺素（PGs）的主要清除部位，TBP可能导致血管舒张性PGs的血液含量增加。在犬身上进行了TBP，并通过生物测定法连续监测前列腺素样物质（PLS）的血液水平。TBP期间PLS的浓度增加至0.8 ng·cm⁻³血液（以PGE2当量计）。恢复正常循环导致PLS从血液中消失。消炎痛消除了TBP期间PLS的增加。这总是伴随着体循环血压的升高。有人认为，TBP期间血管舒张性PLS浓度的增加可能是全身灌注中观察到的低血压的原因。
