Kawamura M, Minamikawa O, Yokochi H, Maki S, Yasuda T, Mizukawa Y
Jpn J Surg. 1982;12(1):19-25. doi: 10.1007/BF02469010.
Effects of prostaglandin E1 (PGE1) and phenoxybenzamine (POB) on the hemodynamics during cardiopulmonary bypass (CPB) were studied in 30 infants and children. Patients were grouped into three; PGE1 was given to ten patients, POB to another ten, and the other ten patients served as the control. Vasodilating drugs were withheld. PGE1 was infused at 0.01 to 0.02 microgram/kg/min during CPB, and POB at 1.0 mg/kg within the initial 10 minutes of bypass. There was a significant drop in arterial and venous pressure at the time of initiation of bypass in both the PGE1 and POB groups. In the PGE1 group in particular, such a stable hemodynamic condition of over 60 mm Hg in mean arterial pressure, 7.5 to 12.5 cmH2O in central venous pressure, 1300 to 1700 dynes . sec . cm -5 in systemic vascular resistance was maintained throughout CPB, as compared with the other two groups. PGE1 contributed to an adequate diuresis and the preservation of platelets. Our findings indicate that PGE1 has potential clinical advantages for application during CPB.
在30例婴幼儿和儿童中研究了前列腺素E1（PGE1）和酚苄明（POB）对体外循环（CPB）期间血流动力学的影响。患者被分为三组；10例患者给予PGE1，另外10例给予POB，其余10例患者作为对照。停用血管扩张药物。CPB期间PGE1以0.01至0.02微克/千克/分钟的速度输注，POB在体外循环开始后的最初10分钟内以1.0毫克/千克的剂量给药。PGE1组和POB组在体外循环开始时动脉压和静脉压均显著下降。特别是在PGE1组中，与其他两组相比，在整个CPB期间平均动脉压超过60毫米汞柱、中心静脉压7.5至12.5厘米水柱、体循环血管阻力1300至1700达因·秒·厘米⁻⁵的稳定血流动力学状态得以维持。PGE1有助于充分利尿和保护血小板。我们的研究结果表明，PGE1在CPB期间应用具有潜在的临床优势。
