Herman A G, Vane J R
Eur J Pharmacol. 1976 Sep;39(1):79-90. doi: 10.1016/0014-2999(76)90115-1.
The appearance of prostaglandins in dog's blood during endotoxin-induced hypotension was studied by use of the dialysis modification of the blood bathed organ technique. An increase in prostaglandins, mainly E2 and F2alpha was found in renal venous blood, whereas no such increase was seen in blood from the abdominal aorta, the inferior vena cava or the femoral vein. Three possible trigger mechanisms for this increase i.e. hypotension, reduced flow and reflexogenic sympathetic stimulation, have been investigated. It is suggested that, in addition to these three factors, circulating hormones such as noradrenaline, angiotensin or bradykinin, play a role in this release mechanism. Administration of indomethacin produced a restoration of the systemic blood pressure to its pre-endotoxin value; concomitantly a disappearance of the prostaglandins from the circulation was observed. It is concluded that prostaglandins contribute to the hypotension induced by endotoxin. Whether they are beneficial or detrimental remains to be resolved.
采用血浴器官技术的透析改良法，研究了内毒素诱导的低血压期间犬血液中前列腺素的出现情况。在肾静脉血中发现前列腺素增加，主要是E2和F2α，而在腹主动脉、下腔静脉或股静脉血中未观察到这种增加。已对这种增加的三种可能触发机制，即低血压、血流减少和反射性交感神经刺激进行了研究。有人认为，除了这三个因素外，循环激素如去甲肾上腺素、血管紧张素或缓激肽在这种释放机制中起作用。给予吲哚美辛可使全身血压恢复到内毒素注射前的值；同时观察到循环中的前列腺素消失。结论是前列腺素促成了内毒素诱导的低血压。它们是有益还是有害仍有待解决。
