Damber J E, Bergh A, Janson P O
Andrologia. 1980 Jan-Feb;12(1):12-9. doi: 10.1111/j.1439-0272.1980.tb00568.x.
Leydig cell function, as judged from testosterone concentrations in plasma and in testicular tissue after LH stimulation, was tested in adult rat testes 4 days after brief exposure of the scrotum to 33 degrees and 43 degrees C, respectively. There was no significant difference in basal plasma testosterone concentrations between the two groups of rats but the response to LH stimulation was significantly depressed in rats exposed to 43 decrees C. Morphological examination of the Leydig cells showed an accumulation of lipid droplets in the cytoplasm of the testes exposed to 43 degrees C, indicating a disturbed steroidogenesis. The spermatogenetic arrest seen after heat treatment of the rat testis is discussed in relation to the present finding of impaired Leydig cell function.
分别在阴囊短暂暴露于33摄氏度和43摄氏度4天后，对成年大鼠睾丸中从LH刺激后的血浆和睾丸组织中的睾酮浓度判断的睾丸间质细胞功能进行了测试。两组大鼠的基础血浆睾酮浓度没有显著差异，但暴露于43摄氏度的大鼠对LH刺激的反应明显降低。对睾丸间质细胞的形态学检查显示，暴露于43摄氏度的睾丸细胞质中脂滴积累，表明类固醇生成受到干扰。结合目前睾丸间质细胞功能受损的发现，讨论了大鼠睾丸热处理后出现的生精停滞现象。
