Vaidyanathan S, Rao M S, Bapna B C, Chary K S, Swamy R P
Ann Clin Res. 1980 Feb;12(1):1-4.
The effect of intravenous administration of 20 mg metoclopramide, a dopamine receptor antagonist upon cystometry, urethral pressure profile and external urethral sphincter electromyography (EMG) was investigated in 10 patients with neurogenic bladder dysfunction. No significant change was noticed in detrusor reflex activity or in peak urethral pressure. This suggests that dopamine receptors are not important in vesicourethral function. The increase in sphincter EMG activity observed was probably due to the cholinergic effect of metoclopramide.
在10例神经源性膀胱功能障碍患者中，研究了静脉注射20毫克多巴胺受体拮抗剂甲氧氯普胺对膀胱测压、尿道压力分布和尿道外括约肌肌电图（EMG）的影响。逼尿肌反射活动或尿道峰值压力未发现明显变化。这表明多巴胺受体在膀胱尿道功能中并不重要。观察到的括约肌肌电图活动增加可能是由于甲氧氯普胺的胆碱能作用。
