Response of mhs swine to i.v. infusion of lignocaine and bupivacaine.

We report the negative response of MHS swine to i.v. infusion of lignocaine and bupivacaine yielding plasma concentrations which equal or exceed those reported in humans during extradural analgesia. It is concluded that local anaesthetic techniques using the amide-linked local anaesthetics administered in conventional dosage are safe to use in patients known to be genetically susceptible to malignant hyperthermia.