地西泮对儿童骶管注射局部麻醉药混合液后布比卡因和利多卡因血浆浓度的影响。
The influence of diazepam on the plasma concentrations of bupivacaine and lignocaine after caudal injection of a mixture of the local anaesthetics in children.
作者信息
Giaufre E, Bruguerolle B, Morisson-Lacombe G, Rousset-Rouviere B
机构信息
Service de Chirurgie pédiatrique, Fondation Hôpital Saint-Joseph, Marseille, France.
出版信息
Br J Clin Pharmacol. 1988 Jul;26(1):116-8. doi: 10.1111/j.1365-2125.1988.tb03376.x.
Abstract
Twenty-one children undergoing surgery received a caudal block using 1 ml kg-1 of a mixture of 50% lignocaine (1%) and 50% bupivacaine (0.25%). They were randomized into two groups, one of which received diazepam 10 mg rectally as premedication. Diazepam administration resulted in significantly higher Cmax and AUC values for bupivacaine but did not influence the plasma concentrations of lignocaine.
摘要
21名接受手术的儿童接受了骶管阻滞，使用的是每千克体重1毫升的50%利多卡因（1%）和50%布比卡因（0.25%）的混合液。他们被随机分为两组，其中一组术前经直肠给予10毫克地西泮。给予地西泮导致布比卡因的Cmax和AUC值显著升高，但不影响利多卡因的血浆浓度。
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