Nilsen K H
Br J Dermatol. 1980 Jan;102(1):1-5. doi: 10.1111/j.1365-2133.1980.tb05664.x.
The main types of underlying mechanism in Raynaud's phenomenon were tested separately in thirty-six patients. Within each of three groups of patients who were clinically classified according to strict definitions as having primary Raynaud's disease, systemic sclerosis or rheumatoid arthritis, there was pathophysiological heterogeneity. It is therefore suggested that in studies of treatment, at least when it is aimed primarily at one pathophysiological mechanism, the patients whould be selected according to the mechanism rather than what is commonly done now, according to the associated disorder.
对36例雷诺现象的主要潜在机制类型分别进行了测试。在根据严格定义临床分类为患有原发性雷诺病、系统性硬化症或类风湿性关节炎的三组患者中，每组均存在病理生理异质性。因此，建议在治疗研究中，至少当主要针对一种病理生理机制时，患者应根据机制进行选择，而不是像现在通常所做的那样，根据相关疾病来选择。
