Chakraborty M, Ghosal J, Biswas T, Datta A G
Indian Institute of Chemical Biology, Calcutta.
Biochem Med Metab Biol. 1988 Aug;40(1):8-18. doi: 10.1016/0885-4505(88)90099-0.
Starved animals having low levels of erythropoietin in blood showed increased MDA, fluorescent pigments, and met-Hb values whereas the hemoglobin concentration decreased significantly on starvation. In vivo and in vitro studies with Ep reversed the effects of starvation and brought these values close to normal. The activities of the enzymes (SOD, catalase, GSH-PX, GR G6PD, and 6PGD) which protect the RBC membrane directly or indirectly from peroxidative threat, decreased on starvation and restored to normal levels after Ep treatment.
血液中促红细胞生成素水平较低的饥饿动物，其丙二醛、荧光色素和高铁血红蛋白值升高，而饥饿时血红蛋白浓度显著降低。促红细胞生成素的体内和体外研究逆转了饥饿的影响，使这些值接近正常水平。直接或间接保护红细胞膜免受过氧化威胁的酶（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶）的活性在饥饿时降低，促红细胞生成素治疗后恢复到正常水平。
