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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Anwyl R, Narahashi T

Br J Pharmacol. 1979 Mar;65(3):483-8. doi: 10.1111/j.1476-5381.1979.tb07855.x.

The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. 2. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. 3. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments.

已经研究了秋水仙碱和细胞松弛素B对大鼠肌肉接头外乙酰胆碱（ACh）受体的影响。2. 秋水仙碱和细胞松弛素B均降低了离子电泳ACh电位的幅度和上升时间。当在这些药物存在的情况下增加ACh剂量时，会产生具有双相波形的ACh电位，该波形由快速的初始相和第二个缓慢相组成。3. 有人提出秋水仙碱和细胞松弛素B的作用机制并非通过微管和微丝的分解。

Anwyl R, Narahashi T

Br J Pharmacol. 1979 Mar;65(3):483-8. doi: 10.1111/j.1476-5381.1979.tb07855.x.

The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. 2. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. 3. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments.

已经研究了秋水仙碱和细胞松弛素B对大鼠肌肉接头外乙酰胆碱（ACh）受体的影响。2. 秋水仙碱和细胞松弛素B均降低了离子电泳ACh电位的幅度和上升时间。当在这些药物存在的情况下增加ACh剂量时，会产生具有双相波形的ACh电位，该波形由快速的初始相和第二个缓慢相组成。3. 有人提出秋水仙碱和细胞松弛素B的作用机制并非通过微管和微丝的分解。