Palkovits M, Záborszky L, Feminger A, Mezey E, Fekete M I, Herman J P, Kanyicska B, Szabó D
Brain Res. 1980 Jun 2;191(1):161-71. doi: 10.1016/0006-8993(80)90320-0.
The concentrations of noradrenaline in individual hypothalamic nuclei and in the median eminence were measured 7-10 days following surgical transections of the lower brain stem or electrolytic lesions of the medullary noradrenaline-containing cell groups. Terminal degeneration in the hypothalamus was studied after the same surgical procedures. Direct, monosynaptic connections between the dorsomedial hypothalamic nucleus and all the noradrenaline-containing cell groups investigated were found. Degenerated synaptic boutons were demonstrated in the median eminence, arcuate, dorsomedial, ventromedial, periventricular and paraventricular nuclei following lesions of the solitary tract and of the lateral reticular nucleus. Biochemical measurements indicate that the pontine-medullary noradrenergic cell groups are the source of hypothalamic norepinephrine. Ascending noradrenergic fibers destined to terminate in the hypothalamus are provided by several cell groups, though the bulk of the NA-fibers seem to originate in the A1-group, in the ventrolateral part of the medullary reticular formation. Most of these fibers join the ventral NA bundle, fewer join the dorsal periventricular tract and several probably also join the dorsal NA bundle. A significant overlap was found in the hypothalamic arborization of the noradrenergic fibers, so that no strict topographical organization seems to be present either in their origin or their termination.
在脑干下部进行手术横断或对延髓含去甲肾上腺素细胞群进行电解损伤7 - 10天后，测量了各个下丘脑核团和正中隆起中的去甲肾上腺素浓度。在相同手术操作后，研究了下丘脑中的终末变性。发现下丘脑背内侧核与所有研究的含去甲肾上腺素细胞群之间存在直接的单突触连接。在孤束和外侧网状核损伤后，在正中隆起、弓状核、背内侧核、腹内侧核、室周核和室旁核中发现了变性的突触小体。生化测量表明，脑桥 - 延髓去甲肾上腺素能细胞群是下丘脑去甲肾上腺素的来源。虽然大部分去甲肾上腺素能纤维似乎起源于延髓网状结构腹外侧的A1组，但有几群细胞为注定终止于下丘脑的上行去甲肾上腺素能纤维提供了来源。这些纤维大多加入腹侧去甲肾上腺素束，较少加入室周背侧束，还有一些可能也加入背侧去甲肾上腺素束。在去甲肾上腺素能纤维的下丘脑分支中发现了明显的重叠，因此在其起源或终止部位似乎都不存在严格的拓扑组织。
