Lin M T, Hoo S L
Can J Physiol Pharmacol. 1980 Jan;58(1):85-8. doi: 10.1139/y80-014.
This study was designed to determine regional distribution of sodium acetylsalicylate in the brain of normothermic rabbits, rabbits with hyperthermia induced by pyrogen administration, and rabbits with hyperthermia induced by infrared irradiation. Increasing body temperature with either leucocytic pyrogen or infrared light irradiation about doubled the concentration of sodium acetylsalicylate in four regions of the brain. This suggests a more rapid penetration of sodium acetylsalicylate into the brain under hyperthermic conditions. This may explain why the drug lowers body temperature more effectively in febrile animals than in afebrile animals.
本研究旨在确定在正常体温的兔子、注射热原诱导发热的兔子以及红外辐射诱导发热的兔子大脑中乙酰水杨酸纳的区域分布。通过白细胞热原或红外光照射使体温升高，可使大脑四个区域的乙酰水杨酸纳浓度增加约一倍。这表明在高温条件下乙酰水杨酸纳进入大脑的速度更快。这或许可以解释为什么该药物在发热动物中比在无热动物中更有效地降低体温。
