脑室内注射6-羟基多巴胺后的超敏反应：与多巴胺耗竭的关系。
Supersensitivity after intraventricular 6-hydroxydopamine: relation to dopamine depletion.
作者信息
Zigmond M J, Stricker E M
出版信息
Experientia. 1980 Apr 15;36(4):436-8. doi: 10.1007/BF01975133.
PMID:7379917
Abstract
6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA utake in rat striatum. The increase response to apomorphine, however, only occurred after greater than 80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.
摘要
6-羟基多巴胺使大鼠纹状体中对左旋多巴的行为反应随多巴胺（DA）及其摄取量的减少而成比例增加。然而，对阿扑吗啡的增强反应仅在DA损失超过80%后才出现。因此，6-羟基多巴胺可能仅在大面积损伤后才诱导突触后变化。
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