14α-羟基-Δ7-甾醇对甾醇生物合成的抑制作用。
Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.
作者信息
Schroepfer G J, Pascal R A, Kandutsch A A
出版信息
Experientia. 1980 May 15;36(5):518. doi: 10.1007/BF01965773.
PMID:7379935
Abstract
5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.
摘要
已发现5α-胆甾-7-烯-3β,14α-二醇和5α-胆甾-7-烯-14α-醇-3-酮是培养的L细胞中洋地黄皂苷可沉淀甾醇合成的有效抑制剂，并能降低这些细胞中HMG-CoA还原酶的活性水平。
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