Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-C-D ring junction-"5alpha,14beta-cholest-7-en-15alpha-ol-3-one and 5alpha,14beta-cholest-7-en-15beta-ol-3-one.
作者信息
Schroepfer G J, Pascal R A, Kandutsch A A
出版信息
Biochem Pharmacol. 1979;28(2):249-52. doi: 10.1016/0006-2952(79)90511-2.
PMID:426840
Abstract
摘要
相似文献
1
Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-C-D ring junction-"5alpha,14beta-cholest-7-en-15alpha-ol-3-one and 5alpha,14beta-cholest-7-en-15beta-ol-3-one.具有非天然顺式C-D环连接的15-氧化甾醇——“5α,14β-胆甾-7-烯-15α-醇-3-酮和5α,14β-胆甾-7-烯-15β-醇-3-酮对动物细胞中甾醇合成的抑制作用。
Biochem Pharmacol. 1979;28(2):249-52. doi: 10.1016/0006-2952(79)90511-2.
2
Inhibition of sterol biosynthesis by 9 alpha-fluoro and 9 alpha-hydroxy derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮的9α-氟和9α-羟基衍生物对甾醇生物合成的抑制作用
Biochem Biophys Res Commun. 1979 Nov 28;91(2):606-13. doi: 10.1016/0006-291x(79)91565-1.
3
Sterol synthesis. Syntheses of 15-oxygenated 5alpha, 14beta-cholest-7-en-3beta-ol derivatives.甾醇合成。15-氧化5α,14β-胆甾-7-烯-3β-醇衍生物的合成。
Chem Phys Lipids. 1977 Jun;19(2):107-13. doi: 10.1016/0009-3084(77)90091-3.
4
Inhibition of sterol synthesis in L cells by 14alpha-ethyl-5alpha-cholest-7-en-15alpha-ol-3-one at nanomolar concentrations.14α-乙基-5α-胆甾-7-烯-15α-醇-3-酮在纳摩尔浓度下对L细胞中甾醇合成的抑制作用。
Biochem Biophys Res Commun. 1977 Nov 21;79(2):406-10. doi: 10.1016/0006-291x(77)90172-3.
5
Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.15-氧化甾醇对L细胞和小鼠肝细胞中甾醇生物合成的抑制作用。
J Biol Chem. 1977 Dec 25;252(24):8975-80.
6
Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.14α-羟基-Δ7-甾醇对甾醇生物合成的抑制作用。
Experientia. 1980 May 15;36(5):518. doi: 10.1007/BF01965773.
7
Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.14α-烷基取代的15-氧化甾醇对动物细胞中甾醇生物合成的抑制作用。
J Lipid Res. 1979 Nov;20(8):994-8.
8
Inhibition of hepatic sterol synthesis and reduction of serum cholesterol in rats by 5alpha-cholest-8(14)-en-3beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮对大鼠肝脏甾醇合成的抑制作用及血清胆固醇的降低
Biochem Biophys Res Commun. 1976 Aug 23;71(4):98409. doi: 10.1016/0006-291x(76)90751-8.
9
Further studies on the inhibition of sterol biosynthesis in animal cells by 15-oxygenated sterols.关于15-氧化固醇对动物细胞中固醇生物合成抑制作用的进一步研究。
Chem Phys Lipids. 1979 Nov;25(3):265-85. doi: 10.1016/0009-3084(79)90111-7.
10
Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.甾醇合成抑制剂。4,4-二甲基-15-氧化甾醇在培养的哺乳动物细胞中对甾醇合成及3-羟基-3-甲基戊二酰辅酶A还原酶活性的化学合成、性质及作用。
Chem Phys Lipids. 1988 Jul;47(3):187-207. doi: 10.1016/0009-3084(88)90012-6.
引用本文的文献
1
Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.14α-羟基-Δ7-甾醇对甾醇生物合成的抑制作用。
Experientia. 1980 May 15;36(5):518. doi: 10.1007/BF01965773.
2
5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
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