14alpha-ethyl-5alpha-cholest-7-ene-3beta,15alpha-diol, an extraodinarily potent inhibitor of sterol biosynthesis in animal cells.
作者信息
Schroepfer G J, Parich E J, Kandutsch A A
出版信息
J Am Chem Soc. 1977 Aug 3;99(16):5494-6. doi: 10.1021/ja00458a051.
PMID:886111
Abstract
摘要
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14alpha-ethyl-5alpha-cholest-7-ene-3beta,15alpha-diol, an extraodinarily potent inhibitor of sterol biosynthesis in animal cells.14α-乙基-5α-胆甾-7-烯-3β,15α-二醇，一种在动物细胞中对甾醇生物合成具有极强抑制作用的物质。
J Am Chem Soc. 1977 Aug 3;99(16):5494-6. doi: 10.1021/ja00458a051.
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Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.15-氧化甾醇对L细胞和小鼠肝细胞中甾醇生物合成的抑制作用。
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Sterol synthesis. Chemical synthesis, structure determination and metabolism of 14 alpha-methyl-5 alpha-cholest-7-en-3 beta, 15 beta-diol and 14 alpha-methyl-5 alpha-cholest-7-en-3 beta, 15 alpha-diol.甾醇合成。14α-甲基-5α-胆甾-7-烯-3β,15β-二醇和14α-甲基-5α-胆甾-7-烯-3β,15α-二醇的化学合成、结构测定及代谢
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Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.甾醇合成抑制剂。4,4-二甲基-15-氧化甾醇在培养的哺乳动物细胞中对甾醇合成及3-羟基-3-甲基戊二酰辅酶A还原酶活性的化学合成、性质及作用。
Chem Phys Lipids. 1988 Jul;47(3):187-207. doi: 10.1016/0009-3084(88)90012-6.
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Inhibition of sterol synthesis in L cells by 14alpha-ethyl-5alpha-cholest-7-en-15alpha-ol-3-one at nanomolar concentrations.14α-乙基-5α-胆甾-7-烯-15α-醇-3-酮在纳摩尔浓度下对L细胞中甾醇合成的抑制作用。
Biochem Biophys Res Commun. 1977 Nov 21;79(2):406-10. doi: 10.1016/0006-291x(77)90172-3.
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Sterol synthesis. A novel reductive rearrangement of an alpha,beta-unsaturated steroidal epoxide; a new chemical synthesis of 5alpha-cholest-8(14)-en-3beta, 15alpha-diol.甾醇合成。一种新型的α,β-不饱和甾体环氧化物的还原重排反应；5α-胆甾-8(14)-烯-3β,15α-二醇的新化学合成方法。
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Sterol synthesis. Chemical synthesis of 3beta-benzoyloxy -14alpha, 15alpha-epoxy-5alpha-cholest-7-ene, a key intermediate in the synthesis of 15-oxygenated sterols.甾醇合成。3β-苯甲酰氧基-14α,15α-环氧-5α-胆甾-7-烯的化学合成，15-氧化甾醇合成中的关键中间体。
Chem Phys Lipids. 1977 Apr;18(3-4):233-9. doi: 10.1016/0009-3084(77)90011-1.
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Sterol synthesis. Syntheses of 15-oxygenated 5alpha, 14beta-cholest-7-en-3beta-ol derivatives.甾醇合成。15-氧化5α,14β-胆甾-7-烯-3β-醇衍生物的合成。
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Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.14α-羟基-Δ7-甾醇对甾醇生物合成的抑制作用。
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