[Effect of prostaglandins E, A1 and F2 alpha on local brain blood circulation in non-narcotized animals].

The effect of prostaglandins (PG) E1, A1, and F2 alpha on the systemic arterial blood pressure, local brain circulation, vascular resistance and oxygen tension in the motor region of the cortex, reticular formation and ventromedial nucleus of the hypothalamus was studied in experiments on non-narcotizied rabbits. Intravenous administration of PGE1 (10 microgram/kg/min); PGA1 (50 microgram/kg/min) and PGF2 alpha (50 microgram/kg/min) produced systemic hypotension accompanied by reduction of the local brain blood flow, vascular resistance and oxygen tension in the cortex and subcortical structures. The most pronounced changes in the systemic arterial blood pressure and local brain blood flow were recorded after PGE1 administration, these changes being less marked after PGA1 and PGF2 alpha injections.