Briukhovetskiĭ V I, Ismailov Sh I, Muratov V K, Suchkov V V
Farmakol Toksikol. 1980 Jan-Feb;43(1):52-5.
The effect of prostaglandins (PG) E1, A1, and F2 alpha on the systemic arterial blood pressure, local brain circulation, vascular resistance and oxygen tension in the motor region of the cortex, reticular formation and ventromedial nucleus of the hypothalamus was studied in experiments on non-narcotizied rabbits. Intravenous administration of PGE1 (10 microgram/kg/min); PGA1 (50 microgram/kg/min) and PGF2 alpha (50 microgram/kg/min) produced systemic hypotension accompanied by reduction of the local brain blood flow, vascular resistance and oxygen tension in the cortex and subcortical structures. The most pronounced changes in the systemic arterial blood pressure and local brain blood flow were recorded after PGE1 administration, these changes being less marked after PGA1 and PGF2 alpha injections.
在未麻醉家兔的实验中，研究了前列腺素（PG）E1、A1和F2α对全身动脉血压、局部脑循环、血管阻力以及大脑皮质运动区、网状结构和下丘脑腹内侧核的氧张力的影响。静脉注射PGE1（10微克/千克/分钟）、PGA1（50微克/千克/分钟）和PGF2α（50微克/千克/分钟）会导致全身低血压，同时伴随着大脑皮质和皮质下结构局部脑血流量、血管阻力和氧张力的降低。静脉注射PGE1后，全身动脉血压和局部脑血流量的变化最为显著，而注射PGA1和PGF2α后的变化则不那么明显。
