Briggs B R, Jackson W P, DuToit E D, Botha M C
Diabetes. 1980 Jan;29(1):68-71. doi: 10.2337/diab.29.1.68.
The frequency distributions of HLA antigens in 25 juvenile-onset diabetics (JOD) and 56 maturity-onset diabetics (MOD) belonging to a southern African black tribe (Xhosa) were compared with those of 153 non-diabetic Xhosa blacks. Unlike the findings in white JODs, there was no increase of B8 or B15 nor a reduced frequency of B7 but an apparently, significantly increased frequency of Bw35 and A2 in both Xhosa JODs and Xhosa MODs respectively. This is the first ethnic group in which an HLA antigen marker has been found for MOD. Furthermore, these findings suggest that diabetes, both JOD and MOD, in white people is a different genetic disease from the diabetes among the Xhosa tribe.
对属于南非一个黑人部落（科萨族）的25名青少年发病型糖尿病患者（JOD）和56名成年发病型糖尿病患者（MOD）的HLA抗原频率分布，与153名非糖尿病科萨族黑人的HLA抗原频率分布进行了比较。与白人青少年发病型糖尿病患者的研究结果不同，科萨族青少年发病型糖尿病患者和科萨族成年发病型糖尿病患者中，B8或B15均未增加，B7频率也未降低，而是Bw35和A2频率分别明显显著增加。这是首个发现成年发病型糖尿病有HLA抗原标记的种族群体。此外，这些研究结果表明，白人中的青少年发病型糖尿病和成年发病型糖尿病与科萨族部落中的糖尿病是不同的遗传性疾病。
