一种用于检测DNA免疫复合物的新型特异性检测方法：其在系统性红斑狼疮中的相关性。
A new specific assay for the detection of DNA immune complexes: its relevance in SLE.
作者信息
Klemp P, Meyers O L, Harley E H
出版信息
Ann Rheum Dis. 1983 Jun;42(3):317-22. doi: 10.1136/ard.42.3.317.
Double-stranded DNA immune complexes (DNA-ICs) were assayed by millipore filtration and deoxyribonuclease digestion in 40 patients with both active and inactive systemic lupus erythematosus (SLE). The assay is superior to the double-stranded DNA antibody (ds ADA) as an indicator of active disease, and, when combined with the total haemolytic complement (CH50) and ds ADA levels it increases the prediction of the relative risk of active disease. A good correlation between actual levels of DNA-ICs and the degree of activity was also shown. We conclude that measurement of DNA-ICs is of value as an additional monitor in the assessment of activity in SLE.
采用微孔过滤和脱氧核糖核酸酶消化法，对40例活动期和非活动期系统性红斑狼疮（SLE）患者的双链DNA免疫复合物（DNA-ICs）进行了检测。作为活动性疾病的指标，该检测方法优于双链DNA抗体（ds ADA），并且与总溶血补体（CH50）和ds ADA水平相结合时，可提高对活动性疾病相对风险的预测能力。DNA-ICs的实际水平与疾病活动程度之间也显示出良好的相关性。我们得出结论，DNA-ICs的检测作为评估SLE活动度的一项辅助监测指标具有重要价值。
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