Myśliwski A, Bigda J, Myśliwska J, Witkowski J M, Sosnowska D
Department of Histology and Immunology, Medical University of Gdańsk, Poland.
Neoplasma. 1995;42(1):15-9.
Natural killer (NK) cytotoxic activity during the growth of melanotic (Ma) and amelanotic (Ab) variants of Bomirski hamster melanoma, in the blood and the spleen, was examined. The melanoma variants differed in their growth rate and metastatic pattern. Ability to form conjugates by effectors with targets and cytotoxic effects were compared. As targets K562 cells and tumor cells were used. It was found that during the growth of Ma melanoma activity of NK cells was not changing but the sensitivity of tumor cells was decreasing. However, during growth of Ab melanoma both NK activity and NK sensitivity were reduced.
研究了博米尔基仓鼠黑色素瘤的黑色素瘤（Ma）和无黑色素瘤（Ab）变体生长过程中，血液和脾脏中自然杀伤（NK）细胞的细胞毒性活性。黑色素瘤变体在生长速率和转移模式上存在差异。比较了效应细胞与靶细胞形成结合物的能力和细胞毒性作用。使用K562细胞和肿瘤细胞作为靶细胞。发现Ma黑色素瘤生长过程中，NK细胞活性没有变化，但肿瘤细胞的敏感性在降低。然而，在Ab黑色素瘤生长过程中，NK活性和NK敏感性均降低。
