Felton C R, Johanson W G
J Appl Physiol Respir Environ Exerc Physiol. 1980 Jun;48(6):1038-44. doi: 10.1152/jappl.1980.48.6.1038.
The technique of estimating pulmonary tissue volume (Vt) by rebreathing a tissue-soluble gas is rapid and noninvasive. We examined the sensitivity of this technique for the estimation of Vt in isolated, perfused canine lungs during the development of pulmonary edema. Vt was 84 +/- 15% (mean +/- SD) of the associated lung weight for lung weights of up to 240% of base line but decreased to 70 +/- 2% when lung weight exceeded 310% of base line. Small rebreathing tidal volumes resulted in significantly smaller values for Vt in edematous lungs. An abrupt increase in pulmonary venous pressure increased lung weight due to vascular distension; Vt measurements detected less than half of this increase, implying that certain portions of the intravascular blood volume are not measured by this technique.
通过重吸入一种可溶解于组织的气体来估算肺组织容量（Vt）的技术快速且无创。我们在肺水肿形成过程中，研究了该技术在离体灌注犬肺中估算Vt的敏感性。对于高达基线值240%的肺重量，Vt为相关肺重量的84±15%（平均值±标准差），但当肺重量超过基线值的310%时，Vt降至70±2%。较小的重吸潮气容积导致水肿肺中Vt值显著减小。肺静脉压力的突然升高因血管扩张而使肺重量增加；Vt测量仅检测到这种增加的不到一半，这意味着该技术无法测量血管内容积的某些部分。
