Huchon G J, Lipavsky A, Pangburn P, Hoeffel J M, Jibelian G, Murray J F
J Appl Physiol (1985). 1985 Nov;59(5):1548-54. doi: 10.1152/jappl.1985.59.5.1548.
To characterize further some of the factors affecting lung tissue soluble-gas rebreathing volume (Vlt), we determined the solubility of acetylene in blood and lung tissue, the influence of the presence of pulmonary edema on tissue solubility, the effects of varying tidal volume (VT), and the tissue volume actually measured in two groups of six anesthetized paralyzed dogs: controls (C) and oleic acid-induced pulmonary edema (OA). Each animal's solubility was used to compute Vlt for comparison with gravimetric lung weight (Ql) and extravascular lung water content (Qwl). Solubility at 37.5 degrees C in blood (0.125 ml X 100 ml-1 X Torr-1) exceeded that in lung tissue (P less than 0.005): C = 0.118 and OA = 0.112 ml X 100 ml-1 X Torr-1 (NS). Vlt, expressed as %Ql, increased with increasing VT (20, 35, and 50 ml/kg) in OA (62.2, 78.9, and 94.7%, respectively, P less than 0.0001) but not in C (92.4, 94.4, and 99.3%, respectively). We conclude that solubility differs in blood and lung tissue but not in normal and edematous lungs, Vlt is not affected by VT in normal dogs but is in those with pulmonary edema, and Vlt measures Ql rather than Qwl.
为了进一步描述影响肺组织可溶气体再呼吸量（Vlt）的一些因素，我们测定了乙炔在血液和肺组织中的溶解度、肺水肿的存在对组织溶解度的影响、潮气量（VT）变化的影响，以及在两组各六只麻醉致瘫犬中实际测量的组织体积：对照组（C）和油酸诱导的肺水肿组（OA）。利用每只动物的溶解度来计算Vlt，以便与重量法测定的肺重量（Ql）和血管外肺含水量（Qwl）进行比较。37.5℃时血液中的溶解度（0.125 ml×100 ml⁻¹×Torr⁻¹）超过肺组织中的溶解度（P＜0.005）：C组为0.118，OA组为0.112 ml×100 ml⁻¹×Torr⁻¹（无显著性差异）。以%Ql表示的Vlt在OA组中随VT增加（20、35和50 ml/kg）而增加（分别为62.2%、78.9%和94.7%，P＜0.0001），但在C组中无变化（分别为92.4%、94.4%和99.3%）。我们得出结论，血液和肺组织中的溶解度不同，但正常肺和水肿肺中的溶解度无差异；Vlt在正常犬中不受VT影响，但在肺水肿犬中受影响；Vlt测量的是Ql而非Qwl。
