气相色谱-质谱碎片分析法对人血浆、尿液和唾液中奥昔哌汀的定量分析。
Quantitative analysis of oxepinac in human plasma, urine and saliva by gas chromatography--mass fragmentography.
作者信息
Hakusui H, Suzuki W, Sano M
出版信息
J Chromatogr. 1980 Apr 11;182(1):47-53. doi: 10.1016/s0378-4347(00)81649-7.
A sensitive and specific method is described for the quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-3-acetic acid (oxepinac) in human plasma, urine and saliva. Oxepinac and internal standard are extracted from acidified plasma, urine or saliva, converted to the corresponding n-propyl esters and analysed by gas chromatography--mass fragmentography using selected ion monitoring. The method is accurate and precise over the range 100 microgram/ml to 1.0 ng/ml. The method has been applied to the analysis of plasma, urine and saliva from healthy volunteers receiving therapeutic doses of oxepinac.
本文描述了一种灵敏且特异的方法，用于定量分析人血浆、尿液和唾液中的6,11-二氢-11-氧代-二苯并[b,e]氧杂䓬-3-乙酸（奥昔平酸）。奥昔平酸和内标从酸化的血浆、尿液或唾液中提取，转化为相应的正丙酯，然后使用选择离子监测通过气相色谱-质谱碎片分析法进行分析。该方法在100微克/毫升至1.0纳克/毫升的范围内准确且精密。该方法已应用于接受治疗剂量奥昔平酸的健康志愿者的血浆、尿液和唾液分析。
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