Chimichi S, Innocenti F, Orzalesi G
J Pharm Sci. 1980 May;69(5):521-3. doi: 10.1002/jps.2600690511.
The thermal behavior of ibuproxam was studied at several temperatures, and the degradation products were separated by column chromatography and ethereal extractions. The resulting products were ibuprofen [2-(4-isobutylphenyl)propionic acid], 1-(4-isobutylphenyl)-ethylamine, 4-isobutylacetophenone, and 4-isobutylacetophenone oxime. The compounds were identified by IR, UV, and NMR spectroscopy and elemental analyses. 4-Isobutylacetophenone was treated with hydroxylamine to give 4-isobutylacetophenone oxime.
在多个温度下研究了异丁普生的热行为，其降解产物通过柱色谱法和乙醚萃取进行分离。得到的产物有布洛芬[2-(4-异丁基苯基)丙酸]、1-(4-异丁基苯基)乙胺、4-异丁基苯乙酮和4-异丁基苯乙酮肟。通过红外光谱、紫外光谱、核磁共振光谱和元素分析对这些化合物进行了鉴定。4-异丁基苯乙酮用羟胺处理得到4-异丁基苯乙酮肟。
