Millard B J, Sheinin E B, Benson W R
J Pharm Sci. 1980 Oct;69(10):1177-9. doi: 10.1002/jps.2600691015.
The decomposition products of propoxyphene during GLC were prepared on a larger scale by heating propoxyphene hydrochloride in the presence of glass wook. They were identified by mass spectrometry and NMR spectroscopy as two isomeric diphenylbutenes and two isomeric products formed by loss of propionic acid. On-column decomposition of proxyphene can be prevented by injection of the compound in solution in a silylating agent.
通过在玻璃棉存在下加热盐酸丙氧芬，更大规模地制备了丙氧芬在气相色谱分析期间的分解产物。通过质谱和核磁共振光谱法将它们鉴定为两种异构二苯丁烯以及两种因丙酸损失而形成的异构产物。通过将化合物注射到硅烷化剂溶液中，可以防止丙氧芬在柱上分解。
