Kirchhoefer R D, Juhl W E
J Pharm Sci. 1980 May;69(5):548-50. doi: 10.1002/jps.2600690518.
A quantitative high-pressure liquid chromatographic method, using a reversed-phase column coupled to a fluorescence detector, was developed to determine salicylic acid in bulk aspirin and plain and buffered aspirin tablets. The aspirin was dissolved, filtered, and injected into the chromatograph; the fluorescence of the salicylic acid was measured at approximately 425 nm. Excipients and impurities did not interfere, and recoveries of 100% were obtained. The method was used to analyze 84 aspirin samples.
建立了一种定量高压液相色谱法，该方法使用反相柱与荧光检测器联用，用于测定原料药阿司匹林以及普通和缓冲阿司匹林片中的水杨酸。将阿司匹林溶解、过滤后注入色谱仪；在约425nm处测量水杨酸的荧光。辅料和杂质不产生干扰，回收率为100%。该方法用于分析84个阿司匹林样品。
