通过改变饮食提高大鼠抗利尿激素生物测定的敏感性。
Increased sensitivity of ADH bio-assay in rats by change in diet.
作者信息
Kappagoda C T, Linden R J, Pashley M
出版信息
J Physiol. 1980 Feb;299:425-35. doi: 10.1113/jphysiol.1980.sp013134.
Abstract
- Water-loaded rats anaesthetized with ethanol were used for the detection of antidiuretic hormone (ADH). 2. Litter-mates were divided into groups and placed on different diets during the fourth week of life directly after weaning, and maintained on their respective diets for approximately 1 month and their sensitivity to vasopressin was determined. 3. The rats maintained on a diet of only vegetable or vegetable plus casein supplement showed a greater sensitivity to exogenous vasopressin than rats maintained on a standard laboratory diet (pellets). 4. It is proposed that the quantitative relationship between ADH and urine flow is dependent upon the previous history of water consumption.
摘要
- 用乙醇麻醉的水负荷大鼠用于抗利尿激素（ADH）的检测。2. 同窝幼鼠在断奶后的第四周直接分组并给予不同饮食，各自维持约1个月的相应饮食，然后测定它们对加压素的敏感性。3. 仅以蔬菜或蔬菜加酪蛋白补充剂为食的大鼠对外源加压素的敏感性高于以标准实验室饮食（颗粒饲料）喂养的大鼠。4. 有人提出，ADH与尿流量之间的定量关系取决于先前的饮水史。
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A method for assaying small amounts of antidiuretic substances with notes on some properties of vasopressin.一种测定少量抗利尿物质的方法及有关加压素某些特性的注释
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A method for the assay of very small amounts of antidiuretic activity with a note on the antidiuretic titre of rat's blood.一种测定极少量抗利尿活性的方法及关于大鼠血液抗利尿效价的注释
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