左心房感受器与抗利尿激素
Left atrial receptors and the antidiuretic hormone.
作者信息
Kappagoda C T, Linden R J, Snow H M, Whitaker E M
出版信息
J Physiol. 1974 Mar;237(3):663-83. doi: 10.1113/jphysiol.1974.sp010503.
Abstract
- Stimulation of left atrial receptors by distending balloons located at the junction between the pulmonary veins and the left atrium and in the body of the left atrium resulted in a diuresis in anaesthetized dogs.2. In the same dogs the diuresis was not consistently associated with a reduction in the antidiuretic activity of plasma as compared with that during the initial control period. The antidiuretic activity of dog plasma was assayed in water-loaded rats anaesthetized with ethanol.3. Intravenous injections of vasopressin suppressed a water diuresis in water-loaded dogs anaesthetized with chloralose. The changes in antidiuretic activity of dog plasma which resulted from these injections were reliably detected by the bio-assay in the rat.4. It is concluded that the diuretic response to the stimulation of left atrial receptors is not accompanied by a reduction in the plasma antidiuretic hormone level.
摘要
通过位于肺静脉与左心房交界处及左心房体部的扩张球囊刺激左心房受体，可使麻醉犬产生利尿作用。
在同一批犬中，与初始对照期相比，利尿作用并不总是与血浆抗利尿活性降低相关。犬血浆的抗利尿活性是在用乙醇麻醉的水负荷大鼠中测定的。
静脉注射加压素可抑制用氯醛糖麻醉的水负荷犬的水利尿作用。通过大鼠体内的生物测定法能够可靠地检测到这些注射所导致的犬血浆抗利尿活性的变化。
得出的结论是，对左心房受体刺激的利尿反应并不伴有血浆抗利尿激素水平的降低。
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