用碱性洗脱法检测亚急性同时给予亚硝酸盐和氨基比林诱导的大鼠肝脏DNA损伤。
Detection by alkaline elution of rat liver DNA damage induced by simultaneous subacute administration of nitrite and aminopyrine.
作者信息
Parodi S, Taningher M, Pala M, Brambilla G, Cavanna M
出版信息
J Toxicol Environ Health. 1980 Jan;6(1):167-74. doi: 10.1080/15287398009529839.
DNA fragmentation induced in the livers of rats by oral treatment with NaNO2 and aminopyrine was evaluated by the alkaline elution technique. Whereas simultaneous administration of the two compounds in a single dose produced only a minimal increase of the DNA elution rate, their intake with drinking water for 20 successive days caused DNA fragmentation comparable to that observed after a single ip injection of 10-20 mg/kg N-nitrosodimethylamine. Either NaNO2 or aminopyrine alone induced borderline DNA damaging effects, if any, in both rats receiving a single dose and those treated for 20 successive days.
通过碱性洗脱技术评估了用亚硝酸钠和氨基比林口服处理大鼠肝脏中诱导的DNA片段化情况。虽然单次同时给予这两种化合物仅使DNA洗脱率有最小程度的增加，但它们连续20天随饮用水摄入导致的DNA片段化程度与单次腹腔注射10 - 20 mg/kg N-亚硝基二甲胺后观察到的相当。单独给予亚硝酸钠或氨基比林，无论是对接受单次剂量的大鼠还是连续20天处理的大鼠，若有DNA损伤作用，都只是处于临界水平。
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