Rehnberg G L, Hein J F, Carter S D, Linko R S, Laskey J W
J Toxicol Environ Health. 1981 Feb;7(2):263-72. doi: 10.1080/15287398109529977.
Mn accumulation, distribution, and disappearance were evaluated in selected tissues of preweanling rats dosed daily with particulate Mn3O4 for 12 or 27 d postpartum. Significant findings include a high rate of Mn absorption and localization in tissues, especially the cerebrum, hypothalamus, and pituitary. In these tissues, the return of Mn concentrations to control levels was much slower when Mn dosing was continued beyond 18-20 d postpartum.
对产后每日给予颗粒状四氧化三锰12天或27天的断奶前大鼠的选定组织中的锰积累、分布和消失情况进行了评估。重要发现包括锰在组织中的高吸收率和定位，尤其是在大脑、下丘脑和垂体中。在这些组织中，产后超过18 - 20天继续给予锰时，锰浓度恢复到对照水平的速度要慢得多。
