Kamei C, Masuda Y, Oka M, Shimizu M
Epilepsia. 1978 Dec;19(6):625-36. doi: 10.1111/j.1528-1157.1978.tb05042.x.
Effects of antiepileptics on both behavioral (TE) and electrographic seizure patterns induced by maximal electroshock were studied simultaneously in the same animal. The results obtained are as follows. All the antiepileptics used in this study depressed the TE seizure. Imipramine, biperiden, and lidocaine also depressed TE seizure, although they are not classified as antiepileptics. Phenobarbital, primidone, trimethadione, carbamazepine, ethosuximide, diazepam, clozapine, and imipramine had a depressant effect on electrographic seizures. However, phenytoin, ethotoin, phenacemide, and acetazolamide did not influence the electrographic seizure, in spite of having a strong effect on TE seizure. The present procedure, i.e., that of simultaneous observation of both behavioral and electrographic seizure patterns induced by maximal electroshock in the same animal, provides information which cannot be obtained from either behavior or EEG observation alone.
在同一动物身上同时研究了抗癫痫药物对最大电休克诱发的行为性（TE）和脑电图癫痫发作模式的影响。获得的结果如下。本研究中使用的所有抗癫痫药物均能抑制TE发作。丙咪嗪、比哌立登和利多卡因虽然未被归类为抗癫痫药物，但也能抑制TE发作。苯巴比妥、扑米酮、三甲双酮、卡马西平、乙琥胺、地西泮、氯氮平和丙咪嗪对脑电图癫痫发作有抑制作用。然而，苯妥英、乙苯妥英、苯乙酰脲和乙酰唑胺尽管对TE发作有很强的作用，但对脑电图癫痫发作没有影响。目前的方法，即在同一动物身上同时观察最大电休克诱发的行为性和脑电图癫痫发作模式，提供了单独从行为或脑电图观察中无法获得的信息。
