Olivetti G, Anversa P, Melissari M, Loud A V
Lab Invest. 1980 May;42(5):559-65.
Surgical constriction of the subdiaphragmatic aorta in young adult male rats induced a 54 per cent hypertrophy (39 per cent thickening) of the wall of the thoracic aorta in 8 days, with no increase in the number of elastic lamellae. Morphometric analysis of the aorta wall showed volume increases of its component smooth muscle cells (57 per cent) elastic laminae (30 per cent), collagen (136 per cent), and endothelium plus subendothelial space (40 per cent). Mean cell volume of smooth muscle cells increased 55 per cent from 272 +/- 11 to 421 +/- 21 cu. mum. (p less than 0.005). The number of smooth muscle cells per centimeter of length of thoracic aorta was 4.2 +/- 0.3 x 10(6) in both control and experimental animals. Thus, aortic medial hypertrophy following aortic stenosis included enlargement but no proliferation of smooth muscle cells. Absolute volume increases in the average smooth muscle cell included the nucleus (27 per cent), myofilaments (47 per cent), mitochondria (62 per cent), rough endoplasmic reticulum (246 per cent), smooth endoplasmic reticulum (23 per cent), and caveolae (37 per cent).
对成年雄性幼鼠的膈下主动脉进行手术缩窄，8天后胸主动脉壁出现了54%的肥大（增厚39%），弹性层数量未增加。对主动脉壁进行形态计量分析显示，其组成成分平滑肌细胞（57%）、弹性层（30%）、胶原蛋白（136%）以及内皮加内皮下间隙（40%）的体积均增加。平滑肌细胞的平均细胞体积从272±11立方微米增加到421±21立方微米，增幅为55%（p<0.005）。对照动物和实验动物的胸主动脉每厘米长度的平滑肌细胞数量均为4.2±0.3×10⁶个。因此，主动脉狭窄后的主动脉中膜肥大包括平滑肌细胞的增大但无增殖。平均平滑肌细胞的绝对体积增加包括细胞核（27%）、肌丝（47%）、线粒体（62%）、粗面内质网（246%）、滑面内质网（23%）和小窝（37%）。
