Liu Dongxu, Jiang David, Efrati Efi, Nguyen Nhung, Pocivavsek Luka
Department of Surgery, The University of Chicago, Chicago, USA.
Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
Ann Biomed Eng. 2025 Jun 24. doi: 10.1007/s10439-025-03776-1.
Endarterectomy, typically in patients with peripheral artery disease, involves arteriotomy closure with a 'patch.' One of its most common long-term complications is restenosis due to arterial wall hyperplasia induced by excessive mechanical stimulation. Methods to reduce surgically induced stress to promote positive long-term outcomes remain an open question.
In this work, an arterial 'punch' approach is proposed to alleviate the stress concentration in arterial walls around the incision/patch anastomotic interface. Intraoperatively, coronary vascular punches are used to create proximal and distal circular arteriotomies for patients undergoing femoral endarterectomy. The surgical procedure is numerically simulated by first opening the vessel wall and subsequently adjusting the boundary condition of the incision to consider the patch's effect. An optimization study is performed by investigating the impact of incision/patch combinations on arterial wall stresses. The optimal punch tip size is identified by obtaining the minimum in-plane principal stress in the arterial wall. A beveled punched hole is also considered to optimize the stress field.
Simulation results show that the stress magnitude in the arterial wall with a punched hole is significantly lower than that in an artery with a sharp vertex. The stress exponentially declines with increasing punch diameter. A beveled hole can further reduce the stress values and the number of high-stress regions.
The arterial punch method can effectively alleviate stress concentration in arterial tissues. Importantly, stress concentration is shown to be sensitive to punched hole size and shape, suggesting potential practical implications for surgical techniques and patient outcomes.
动脉内膜切除术通常用于外周动脉疾病患者,术中需用“补片”闭合动脉切开处。其最常见的长期并发症之一是由于过度机械刺激导致动脉壁增生引起的再狭窄。降低手术引起的应力以促进良好长期预后的方法仍是一个悬而未决的问题。
在本研究中,提出了一种动脉“打孔”方法,以减轻切口/补片吻合界面周围动脉壁的应力集中。术中,对于接受股动脉内膜切除术的患者,使用冠状动脉血管打孔器在近端和远端创建圆形动脉切口。通过首先打开血管壁,随后调整切口的边界条件以考虑补片的作用,对手术过程进行数值模拟。通过研究切口/补片组合对动脉壁应力的影响进行优化研究。通过获取动脉壁中的最小面内主应力来确定最佳打孔器尖端尺寸。还考虑了斜切孔以优化应力场。
模拟结果表明,有打孔的动脉壁中的应力大小明显低于有尖锐顶点的动脉中的应力大小。应力随着打孔直径的增加呈指数下降。斜切孔可进一步降低应力值和高应力区域的数量。
动脉打孔方法可有效减轻动脉组织中的应力集中。重要的是,应力集中显示出对打孔尺寸和形状敏感,这对手术技术和患者预后具有潜在的实际意义。