Calabrese E J
Med Hypotheses. 1980 Jan;6(1):21-33. doi: 10.1016/0306-9877(80)90028-6.
It is proposed that oral contraceptive (OC) users are at increased risk to experiencing adverse psychological disorders (e.g. irritability, depression) from exposures to elevated levels of carbon disulfide (CS2). This theory is based on studies indicating that both OCs and CS2 induce either a vitamin B6 deficiency and/or enhance its requirement. Since disruptions of B6 metabolism are thought to explain, at least in part, the adverse psychological effects of OCs and CS2, it is speculated that joint exposure to these substances may result in an exaggerated disruption of B6 metabolism with the development of CS2 induced adverse psychological effects occurring at exposure levels below those normally associated with adverse effects.
有人提出，口服避孕药（OC）使用者因接触高水平的二硫化碳（CS2）而患不良心理障碍（如易怒、抑郁）的风险增加。该理论基于一些研究，这些研究表明，口服避孕药和二硫化碳都会导致维生素B6缺乏和/或增加其需求量。由于维生素B6代谢紊乱被认为至少部分解释了口服避孕药和二硫化碳的不良心理影响，因此推测同时接触这些物质可能会导致维生素B6代谢的过度紊乱，在低于通常与不良反应相关的接触水平时就会出现二硫化碳引起的不良心理影响。
