[Modification of the DNA of bacteriophage Sd in situ by O-beta-diethylaminoethylhydroxylamine].

The interaction of a O-derivated analog of hydroxylamine-O-beta-diethylaminoethyl-hydroxylamine (OHA) with bacteriophage SD DNA in situ was studied. It was established that OHA modifies the cytidine of phage DNA up to 2% from the total cytidine quantity. The terminal ratio products of modification cytidine corresponds to the ration of modification products for completely denaturated DNA. The results obtained are interpreted in terms of locally denaturated regions spaced in the whole genome of SD bacteriophage.