Mårtensson L, Sjöquist P O, Bjellin L, Carter A M
Eur J Pharmacol. 1978 Dec 15;53(1):57-62. doi: 10.1016/0014-2999(78)90267-4.
The effect of terbutaline sulphage, a beta-adrenergic agonist, on uteroplacental blood flow was studied in the guinea pig during late pregnancy. Organ blood flows and cardiac output were assessed by the radioactive microsphere technique. Infusion of terbutaline at a rate of 2nmol min-1 kg-1 body weight caused a significant increase in cardiac output and in the perfusion of the uterus and ovaries, but there was no significant alteration in maternal placental blood flow. When the infusion rate was increased tenfold, there was also a significant rise in the blood supply to the bronchi, urinary bladder, kidneys, and adrenal glands. Maternal placental blood flow was not adversely affected even by this large dose of the drug, although there was a significant reduction in the placental share of the cardiac output.
在妊娠晚期的豚鼠中，研究了β-肾上腺素能激动剂硫酸特布他林对子宫胎盘血流的影响。采用放射性微球技术评估器官血流量和心输出量。以2nmol min-1 kg-1体重的速率输注特布他林，可使心输出量以及子宫和卵巢的灌注显著增加，但母体胎盘血流量无明显改变。当输注速率增加10倍时，支气管、膀胱、肾脏和肾上腺的血液供应也显著增加。即使使用大剂量的该药物，母体胎盘血流量也未受到不利影响，尽管心输出量中胎盘所占份额显著降低。
