Oyanagi K, Nakamura K, Sogawa H, Tsukazaki H, Minami R, Nakao T
Pediatr Res. 1980 Mar;14(3):236-41. doi: 10.1203/00006450-198003000-00012.
The urea-synthesizing enzymes of human liver tissues, namely, carbamylphosphate synthetase (CPS, EC 2.7.2.2), ornithine transcarbamylase (OTC, EC 2.1.3.3), arginine synthetase system, argininosuccinase (ASase, EC 4.3.2.1), and arginase (EC 3.5.3.1) were measured between pre- and postnatal periods. Specimens from 67 autopsied human livers obtained from fetuses, premature infants, newborn infants, infants, children, and adults were examined. The mean activities of the enzymes showed an increased pattern for OTC and arginase at fetal life, whereas those of CPS, arginine synthetase system, and ASase of fetal livers showed no significant difference in each stage. Except for arginase, the other four enzyme activities were higher in the postnatal period than those in the fetal life. Arginase activities indicated maximal increase at a gestational age between 28 and 31 weeks and decreased in the postnatal life.
对人肝组织中尿素合成酶，即氨甲酰磷酸合成酶（CPS，EC 2.7.2.2）、鸟氨酸转氨甲酰酶（OTC，EC 2.1.3.3）、精氨酸合成酶系统、精氨琥珀酸酶（ASase，EC 4.3.2.1）和精氨酸酶（EC 3.5.3.1）在出生前和出生后的阶段进行了测定。对从胎儿、早产儿、新生儿、婴儿、儿童和成人获取的67例尸检人肝标本进行了检查。酶的平均活性显示，胎儿期OTC和精氨酸酶呈增加模式，而胎儿肝脏的CPS、精氨酸合成酶系统和ASase在各阶段无显著差异。除精氨酸酶外，其他四种酶活性在出生后高于胎儿期。精氨酸酶活性在孕龄28至31周时显示最大增加，出生后降低。
