Whalley L J, Yates C M, Christie J E
Psychol Med. 1980 May;10(2):377-80. doi: 10.1017/s0033291700044159.
The concentrations of total and free plasma tryptophan were measured in 12 unipolar depressed patients before and after a course of electroconvulsive therapy (ECT) and before and after single ECTs during the course of treatment. Eleven patients undergoing diagnostic cystoscopy served and controls to examine the acute effect of anaesthesia. Total and free plasma tryptophan concentrations in the depressed patients were not significantly different from control values and were not changed by course of ECT. Free plasma tryptophan varied considerably within individual patients. Total plasma tryptophan was reduced acutely by ECT/anaesthesia in the depressed patients (P less than 0.05) and by anaesthesia in the cystoscopy controls (P less than 0.01). Free plasma tryptophan was not significantly altered. This reduction in total plasma tryptophan could be secondary to an effect of thiopentone on albumin binding of tryptophan.
在12例单相抑郁症患者接受一个疗程的电休克治疗（ECT）之前和之后，以及在治疗过程中单次ECT治疗之前和之后，测量了血浆总色氨酸和游离色氨酸的浓度。11例接受诊断性膀胱镜检查的患者作为对照，以研究麻醉的急性效应。抑郁症患者的血浆总色氨酸和游离色氨酸浓度与对照值无显著差异，且不会因ECT疗程而改变。个体患者的游离血浆色氨酸变化很大。抑郁症患者的总血浆色氨酸在ECT/麻醉后急性降低（P<0.05），膀胱镜检查对照组在麻醉后也降低（P<0.01）。游离血浆色氨酸无显著改变。总血浆色氨酸的这种降低可能继发于硫喷妥钠对色氨酸白蛋白结合的影响。
