Castaneda-Zuniga W R, Formanek A, Tadavarthy M, Vlodaver Z, Edwards J E, Zollikofer C, Amplatz K
Radiology. 1980 Jun;135(3):565-71. doi: 10.1148/radiology.135.3.7384437.
A new theory of the mechanism of percutaneous arterial angioplasty is advanced. For this study, abdominal aortas and coronary, renal, superior mesenteric, and iliac arteries were obtained from cadavers. In addition, the iliac arteries of dogs were dilated and studied. No evidence of significant compression or redistribution of plaques could be found, supporting the theory that atheromatous material is incompressible. Cracking of the intima and separation of it from the media were histologically demonstrated following angioplasty. It is proposed that the stretched media distends following dilatation, carrying with the intima and atheromatous material. Once the media is freed from the encasing effect of the intima, it adapts to the circulatory needs of the body. Beyond a certain point, the arterial widening becomes permanent, due to an overstretching of the muscle fibers, which is demonstrated by a corkscrew deformity of the muscle cell nuclei.
一种经皮动脉血管成形术机制的新理论被提出。在本研究中，从尸体获取腹主动脉以及冠状动脉、肾动脉、肠系膜上动脉和髂动脉。此外，对犬的髂动脉进行扩张并研究。未发现斑块有明显压缩或重新分布的证据，这支持了动脉粥样硬化物质不可压缩的理论。血管成形术后，组织学显示内膜出现破裂并与中膜分离。有人提出，扩张后被拉伸的中膜会膨胀，带动内膜和动脉粥样硬化物质。一旦中膜摆脱内膜的包裹作用，它就会适应身体的循环需求。超过一定程度后，由于肌纤维过度拉伸，动脉扩张会变为永久性的，这通过肌细胞核的螺旋状畸形得以证明。
