血管活性肠肽在兔皮肤中作为血管扩张剂和水肿增强剂比前列腺素E2更有效。
Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and oedema potentiator in rabbit skin.
作者信息
Williams T J
出版信息
Br J Pharmacol. 1982 Nov;77(3):505-9. doi: 10.1111/j.1476-5381.1982.tb09324.x.
Abstract
1 The 28 amino acid polypeptide, vasoactive intestinal polypeptide (VIP) induced increased local blood flow when injected intradermally in the rabbit. 2 VIP was found to be even more potent than prostaglandin E2 (PGE2) in increasing blood flow; VIP induced a significant effect at a 1 pmol dose. 3 VIP was shown to be poor in increasing microvascular permeability but very potent in enhancing local oedema induced by two substances which increase permeability, bradykinin and C5a des Arg. VIP was more potent than PGE2 as an oedema potentiator. 4 Indomethacin had no effect on oedema potentiation induced by VIP, suggesting that a release of endogenous prostaglandins was not involved. 5 These results support our hypothesis for the regulation of oedema formation by arteriolar vasodilators, although the observations do not exclude the possibility of additional regulation by agonist interaction in the region of the venule. 6 VIP may be involved in the physiological control of normal blood flow and in hyperaemia in some types of inflammatory reactions.
摘要
28个氨基酸的多肽——血管活性肠肽（VIP），经皮内注射到兔子体内时会引起局部血流增加。
发现VIP在增加血流量方面比前列腺素E2（PGE2）更有效；VIP在1皮摩尔剂量时就能产生显著效果。
研究表明，VIP在增加微血管通透性方面作用较弱，但在增强由两种增加通透性的物质——缓激肽和C5a去精氨酸诱导的局部水肿方面非常有效。作为水肿增强剂，VIP比PGE2更有效。
吲哚美辛对VIP诱导的水肿增强作用没有影响，这表明内源性前列腺素的释放未参与其中。
这些结果支持了我们关于小动脉血管扩张剂调节水肿形成的假说，尽管这些观察结果并不排除在小静脉区域通过激动剂相互作用进行额外调节的可能性。
VIP可能参与正常血流的生理控制以及某些类型炎症反应中的充血过程。
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